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Carbonic Anhydrase Catalysis.pdf
CompletedProton Transfer in Human CA II.pdf
CompletedLehninger Principles of Biochemistry.epub
CompletedAcidic conditions protonate the zinc-bound hydroxide needed for CO₂ attack, while also slowing proton transfer through His64.
The zinc-bound hydroxide is the nucleophile that attacks carbon dioxide. Below the apparent pKa, protonation of this group sharply reduces catalytic activity. Regeneration of the active form then depends on proton transfer through His64 to the surrounding buffer.
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